High mobility group at hook 2
骨髄増殖性腫瘍の分子病態 ―high mobility group at-hook 2（hmga2）の役割― 池田 和彦１）２） 真性赤血球増加症，本態性血小板血症，原発性骨髄 線維症を含む. 2translational cancer research group, a coruña biomedical research high mobility group b (hmgb) proteins have been previously related to to the hmg family and are characterized by the “at hook” domain for dna. There is a clear link between overweight, gain of white adipose tissue, and diabetes type 2 (t2d) the molecular mechanism of the gain of adipose tissue is linked with the expression of high mobility group protein at-hook 2 (hmga2), and recent studies revealed an association with a snp near hmga2 in this study , we. The mammalian hmgic/y (hmga also see 600701) nonhistone chromosomal proteins, which are often referred to as architectural proteins, participate in a wide variety of cellular processes including regulation of inducible gene transcription, integration of retroviruses into chromosomes, and the induction of neoplastic. The hmga proteins have three at-hook domains and an acidic c-terminal tail the hmga2 modifications consist in the loss of the c-terminal tail and fusion with. High mobility group at-hook 2 (hmga2) protein is composed of three at-hook domains hmga2 expresses at high levels in both embryonic stem cells and cancer cells, where it interacts with and stabilizes replication forks (rfs), resulting in elevated cell proliferation rates in this study, we demonstrated that hmga2.
Functions as a transcriptional regulator functions in cell cycle regulation through ccna2 plays an important role in chromosome condensation during the meiotic g2/m transition of spermatocytes plays a role in postnatal myogenesis, is involved in satellite cell activation (by similarity. High mobility group (hmg) box domains are involved in binding dna, and may and can be broadly divided into two groups, based on sequence-dependent. The molecular mechanism of the gain of adipose tissue is linked with the expression of high mobility group protein at-hook 2 (hmga2), and recent studies.
Moreover, obesity is a major risk factor that enhances the risk of developing other diseases such as insulin resistance, type 2 diabetes and as high mobility –at- hook- group-1 (hmga1) proteins have been implicated on adipogenesis in vitro, we sought to examine the metabolic effects of hmga1. Nanoscale assembly of high-mobility group at-hook 2 protein with dna replication fork natalie krahn,1 markus meier,1 vu to,1 evan p booy,1 kevin mceleney,1,2 joe d o'neil,1 sean a mckenna,1,2,3 trushar r patel,4,5,6, and jцrg stetefeld1,7, 1department of chemistry, 2manitoba institute.
High-mobility group at-hook 2, also known as hmga2, is a protein that, in humans, is encoded by the hmga2 gene contents [hide] 1 function 2 regulation by let-7 3 clinical significance 31 relationship with cancer 32 characteristic mutations in hmga2-high cancers 33 ercc1 34 chromatin immunoprecipitation. Gene name, hmga2 (hgnc symbol) synonyms, babl, hmgic, lipo description, high mobility group at-hook 2 (hgnc symbol) entrez gene summary, this gene encodes a protein that belongs to the non-histone chromosomal high mobility group (hmg) protein family hmg proteins function as architectural factors and. High mobility group at-hook 2 [source:hgnc symbolacc:hgnc:5009] synonyms babl, hmgic, lipo location chromosome 12: 65,824,131- 65,966,295 forward strand grch38:cm0006742 about this gene this gene has 11 transcripts (splice variants), 76 orthologues, is a member of 2 ensembl protein families and.
High mobility group at hook 2
Hmg-i/y bind preferentially to the minor groove of a+t rich regions in double- stranded dna it is suggested that these proteins could function in nucleosome phasing and in the 3'-end processing of mrna transcripts they are also involved in the transcription regulation of genes containing, or in close proximity to a+t-rich.
- It was reported that the oncogenic proepithelial mesenchymal transition (emt) high mobility group at-hook 2 gene (hmga2) mediates the antimetastatic function of ttf-1 to gain mechanistic insight into the metastasis-critical signaling axis of ttf-1 to hmga2, we used both reverse and forward strategies.
- Hmga2, a high-mobility group protein, is oncogenic in a variety of the regulation of high mobility group at-hook 2 gene (hmga2) by.
- The high mobility group a (hmga) family includes three proteins: hmga1a, hmga1b, (encoded by the same gene through alternative splicing) and hmga2 these proteins bind the minor groove of at-rich dna sequences through three short basic repeats, named 'at-hooks', thereby altering chromatin.
Complete information for hmga2 gene (protein coding), high mobility group at- hook 2, including: function, proteins, disorders, pathways, orthologs, and expression genecards - the human gene compendium. High-mobility group (hmg) proteins are heterogeneous non-histone dna- binding factors that organize active chromatin (1) high-mobility group at-hook protein 2 (hmga 2) belongs to this family and is located at chromosome 12q14 and encodes an 109 amino acid protein the functional unit of all hmga. Hook (hmga2) as being frequently upregulated in esophageal results: four genes [high-mobility group at-hook 2 (hmga2), paternally.